PRF PRP Surgery
Dr. Chirag Chamria, Oral & Maxillofacial Surgeon at Royal Dental Clinics discussing PRP & PRF. So, heres Dr. Chirag Chamria explaining the science behind PRP & PRF and its myriad uses in dentistry.

What is PRP (platelet rich plasma)?

PRP is platelet-rich plasma. It’s used in various surgical fields. In addition, it consists of a high concentration of platelets and fibrinogen. As platelets play an important role in wound healing, PRP is also an induced addition to enhance wound healing after surgical dental procedures. Both PRP and PRF are different but have similar benefits for healing.

How is PRP made?

It consists of a gel thats formed by mixing PRP, derived from centrifugation of autologous whole blood with thrombin and calcium chloride. Adding thrombin and calcium chloride activates alpha granules which release growth factors. Growth factors such as PDGF TGF beta VEGF, EGF. 

platelet rich plasma for dental procedures

What are the uses of PRP in dental surgery?

The effects of PRP on healing the alveolar socket after tooth extraction.

Soft tissue healing significantly improves in patients treated with PRP, compared with patients of the controlled group that is no treatment.

The use of PRP in periodontal surgery.

A recent systematic review stated that PRP in periodontal therapy is capable of improving gingival recession but not clinically attached levels in chronic periodontitis. 

PRP in oral surgery. 

Khairy et al 2012 evaluated the bone quality in sinuses which had been augmented with autogenous bone with or without PRP.  However, it concluded that PRP did not significantly improve bone density at 3 months post grafting but PRP-enriched bone graft was associated with superior bone density at 6 months.

What are the disadvantages of PRP?

Cost versus outcome; PRP is the advanced technique for tissue regeneration, hence higher on the price. The treatment outcome may vary from being beneficial. However, the cost factor out ways the post treatment results. Compared to PRF, procurement of PRP is a lengthy procedure consuming time.

What is PRF (Platelet-rich fibrin)?

Platelet-rich fibrin (PRF) also called Choukroun’s platelet-rich fibrin named after its inventor. Whenever there is a loss of support of an affected tooth, and the bone into which they are inserted; regenerative procedures like PRF are carried out. Regeneration or repair of the expected healing outcome following periodontal therapy. However, this depends on two crucial events: the availability of cell types needed and the presence or absence of signals necessary to stimulate the cells. Growth factors favor wound healing by promoting the proliferation of cells (mitogenesis), migration of cells (chemotaxis), and stimulation of new blood vessel formation (angiogenesis).

How is PRF made?

For preparation of PRF, only centrifuged blood without any addition of anticoagulant and bovine thrombin is required. In addition, blood sample is taken without anticoagulant in 10-mL tubes in a glass or glass-coated plastic tube and immediately centrifuged at 3000 rpm for 10 minutes. The resultant product consists of the following three layers. Top-most layer consisting of an acellular plasma, PRF clot in the middle, and a red corpuscle base at the bottom. Compression between two sterile gauzes or in a specific PRF tool enables the clot to be transformed into a membrane.


What are the uses of PRF in dental surgery?

PRF is used in cases of periodontal regeneration, sinus lift, gingival recession, and perio-endo lesions. The advantages of this same are:

  1. Firstly, simplified preparation and efficient technique
  2. Secondly, accelerates the healing rate of the grafted bone
  3. It is available through an autologous blood sample
  4. Minimal blood manipulation
  5. It can be used solely or in combination with other grafts
  6. The natural fibrin framework with growth factors impart prolonged stimulation regeneration
  7. Above all, when used along with bony grafts, it is a quick as well as economical alternative when compared with recombinant growth factors


We at Royal Dental Clinics are equipped with a Remi centrifugal machine which helps us to procure platelet-rich plasma and PRF immediately and carry out full mouth rehabilitation cases in a single day thereby facilitating healing of immediate implant cases.

In conclusion, both treatment options PRF and PRP have evolved in the long run. Each of them have a remarkable value in speedy recovery and enhanced healing after surgical dental procedures. These effects are also gained while their use in cosmetic surgeries.

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1 Comment

  1. Royal Dental Clinics are equipped with Remi centrifugal machine which helps us to procure platelet rich plasma and PRF immediately and carry out full mouth rehabilitation cases. Best clinic in Mumbai.

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